Melanoma Cytotoxicity of Buthionine Sulfoximine (BSO) Alone and in Combination with 3,4-Dihydroxybenzylamine and Melphalan
نویسندگان
چکیده
منابع مشابه
Cytotoxic agents Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy
Patients with high-risk neuroblastoma (NB) initially respond to aggressive, alkylator-based therapy only to die from recurrent disease that is refractory to chemotherapy, including alkylating agents. We examined the ability of buthionine sulfoximine (BSO)-mediated glutathione (GSH) depletion to modulate melphalan (LPAM) resistance in five NB cell lines established after progressive disease foll...
متن کاملButhionine sulfoximine and myeloablative concentrations of melphalan overcome resistance in a melphalan-resistant neuroblastoma cell line.
BACKGROUND Alkylator resistance contributes to treatment failure in high-risk neuroblastoma. Buthionine sulfoximine (BSO) can deplete glutathione and synergistically enhance in vitro sensitivity to the alkylating agent melphalan (L-PAM) for many neuroblastoma cell lines, but optimal use of this combination needs to be defined because clinical responses have been less frequent and not durable. ...
متن کاملPhotodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain.
BACKGROUND AND OBJECTIVE The reactive oxygen mechanisms associated with cell damage after photodynamic therapy (PDT) may be exploited to enhance tumor destruction. Pharmacological reduction of glutathione (GSH), an inhibitor of reactive oxygen species, can be induced by administration of buthionine sulfoximine (BSO). STUDY DESIGN/MATERIALS AND METHODS BSO was administered in combination with ...
متن کاملGlutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity.
Taxol is a naturally occurring chemotherapeutic agent that is active against a variety of tumors. Taxol is believed to act by binding tightly to microtubules and preventing their disaggregation. Others have shown that depletion of cellular glutathione results in the disaggregation of microtubules, presumably by allowing the oxidation of some or all of the cysteine residues in tubulins. We studi...
متن کاملPharmacokinetics of Buthionine Sulfoximine (NSC 326231) and Its Effect on Melphalan-induced Toxicity in Mice1
Intravenous doses of buthionine sulfoximine (BSO, NSC 326231), an inhibitor of glutathione synthesis, were eliminated rapidly from mouse plasma in a biexponential manner. The initial phase of the plasma concentration versus time curve had a half-life of 4.9 min and accounted for 94% of the total area under the curve. The half-life of the terminal phase of the curve was 36.7 min and the area acc...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1992
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12616629